We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CASE REPORT.
- Abstract
Albumin, a serum transport protein, provides 80% of colloid osmotic pressure. Congenital analbuminemia (CAA) is an autosomal recessive disorder characterized by absence of serum albumin. Fifty cases of CAA have been reported throughout the world; however, little is known about its clinical impact. Most reported cases have few clinical signs and symptoms. Twelve local cases from the northwestern central plains region in Saskatchewan were identified and reviewed to ascertain morbidity and mortality related to CAA. All of the cases were from two remote First Nations communities. Cases had frequent hospital admissions and recurrent respiratory tract infections. Placental abnormalities included hydropic placentas, placental infarcts and microcalcifications. One-half of the cases were born preterm and one-quarter were small for their gestational age. There were three mortalities in the case series. The present case series suggests increased morbidity and mortality during infancy in patients with CAA. The long-term risks of CAA in this population are unknown and a longitudinal study is recommended.
- Subjects
ALBUMINS; CARRIER proteins; AUTOSOMAL recessive polycystic kidney; HUMAN abnormalities; SYMPTOMS
- Publication
Paediatrics & Child Health (1205-7088), 2012, Vol 17, Issue 6, p297
- ISSN
1205-7088
- Publication type
Article