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- Title
Safety and effectiveness of intravenous thrombolysis with recombinant tissue plasminogen activator in eighty years and older acute ischemic stroke patients.
- Authors
CHEN, Y.; LI, C-H; WANG, Y.-X.; ZHANG, C.-H.; DONG, Z.; ZHANG, F.-F.; WANG, J.-H.; ZHANG, P.-L.
- Abstract
OBJECTIVE: To explore the safety and efficacy of intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) in elderly (≥80 years old) acute ischemic stroke (AIS) patients. PATIENTS AND METHODS: The clinical data of patients who were treated in Tianjin Huanhu Hospital from June 2012 to November 2013 were retrospectively analyzed; amongst them 404 patients had received IVT with rt-PA and 200 patients had not received IVT. Among ≥80 years' old patients, 204 had received IVT and 200 had not. And, the 404 patients who had received IVT, they were divided into two subgroups: elderly (80 years of age; n = 204) and controls (< 80 years old; n = 200). The incidence of intracranial hemorrhage (ICH) and symptomatic intracranial hemorrhage (sICH), case-fatality rate, and other prognostic indicators were compared. RESULTS: Among all ≥80 years' old patients, the IVT subgroup had significantly superior good outcome rates than the non-IVT subgroup at 24-h and 3-month, along with significantly lower case-fatality rate. But for the patients those who had received IVT, the incidence of ICH and the 7-day case-fatality rate were not significantly increased in both the elderly and control subgroups. The 24-h and 3-month good outcome rates were not significantly different between these two subgroups as well. CONCLUSIONS: IVT with rt-PA is a safe and effective treatment for ≥80 year's old AIS patients.
- Subjects
THROMBOLYTIC therapy; CEREBRAL ischemia treatment; STROKE treatment; DRUG therapy; TISSUE plasminogen activator; PLASMINOGEN activators; CIRCULATING anticoagulants; THERAPEUTICS
- Publication
European Review for Medical & Pharmacological Sciences, 2015, Vol 19, Issue 10, p1852
- ISSN
1128-3602
- Publication type
Article