We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms.
- Authors
MINGYUE HUANG; JUNFEI DAI; XIANLIANG ZHONG; JIN WANG; JIANZHONG XU; BO DU
- Abstract
Chronic subdural hematoma (CSDH) is a disease characterized by capsuled blood products that progressively occupy the intracranial space, causing intracranial hypertension and compression in the brain. CSDH frequently occurs in all demographics, especially in the elderly, but the pathogenesis of CSDH remains unclear. In this review, we discuss the origin, development, and current treatment strategies of CSDH. For the first time, we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation, a complex early-stage interactive event in hematoma pathogenesis. We hypothesize that in patients with CSDH, dural border cells (DBCs) might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury, thereby encapsulating the hemorrhage. Membrane formation may trigger inflammatory responses after subdural hemorrhage, promoting fibroblast-involved extracellular matrix (ECM) deposition and aberrant angiogenesis within the outer membrane. Consequently, ECM deposition and angiogenesis mutually influence each other and are modulated by inflammatory processes. By illustrating the complex and interactive mechanism of neomembrane formation, we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.
- Subjects
SUBDURAL hematoma; INTRACRANIAL hypertension; BIOLOGICAL membranes; HEMORRHAGE; EXTRACELLULAR matrix
- Publication
Biocell, 2024, Vol 48, Issue 6, p889
- ISSN
0327-9545
- Publication type
Article
- DOI
10.32604/biocell.2024.050097