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- Title
Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention.
- Authors
Koscik, Rebecca L.; La Rue, Asenath; Jonaitis, Erin M.; Okonkwo, Ozioma C.; Johnson, Sterling C.; Bendlin, Barbara B.; Hermann, Bruce P.; Sager, Mark A.
- Abstract
Aim: It is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was to compare 3 psychometric methods of identifying amnestic mild cognitive impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. Methods: Wisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over approximately 6 years were coded as meeting each of 3 psychometric aMCI definitions: (a) 'aMCI standard-baseline' used published norms to establish cutoffs for baseline performance; (b) 'aMCI robust-baseline' applied WRAP-specific robust norms to baseline, and (c) 'aMCI robust-multiwave' applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset. Results: Half the aMCI standard-baseline and one third of the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI × age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over 6 years of follow-up. Conclusion: Both cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts. © 2014 S. Karger AG, Basel
- Subjects
WISCONSIN; ALZHEIMER'S disease risk factors; COGNITION disorders diagnosis; HYPOTHESIS; AGE distribution; BIOMARKERS; COMPARATIVE studies; CONFIDENCE intervals; FACTOR analysis; LONGITUDINAL method; MEMORY disorders; PSYCHOLOGICAL tests; PSYCHOMETRICS; RESEARCH funding; SECONDARY analysis; CONTROL groups; REPEATED measures design; DISEASE progression; EARLY diagnosis; STATISTICAL models; DESCRIPTIVE statistics
- Publication
Dementia & Geriatric Cognitive Disorders, 2014, Vol 38, Issue 1/2, p16
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000355682