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- Title
Changes in TRPV1-Immunoreactive Neurons in Spinal Nerve Sensory Ganglion Neurons in Rats on Exposure to Capsaicin.
- Authors
Porseva, V.; Shilkin, V.; Korzina, M.; Korobkin, A.; Maslyukov, P.
- Abstract
The morphological characteristics of TRPV1-immunoreactive neurons were studied in thoracic spinal nerve sensory ganglia in rats aged 10, 20, 30, 60, and 90 days in normal conditions and after chemical deafferentation by s.c. administration of capsaicin (100 mg/kg) on the second day of life. TRPV1-immunoreactive neurons differed in terms of their morphological characteristics: immunopositive cells were very small and small in size, and immunonegative cells were small, intermediate, and large in size. Treatment of neonatal rats with capsaicin changed the developmental dynamics of TRPV1-positive neurons, with a decrease in the mean cross-sectional area of cells and decreases in the numbers of these cells throughout the observation period.
- Subjects
TRP channels; SPINAL nerves; SENSORY neurons; LABORATORY rats; CAPSAICIN; SPINAL ganglia; ONTOGENY
- Publication
Neuroscience & Behavioral Physiology, 2012, Vol 42, Issue 7, p770
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-012-9633-8