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- Title
Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program.
- Authors
Desalermos, Athanasios; Russell, Baylee; Leggett, Cecilia; Parnell, Amelia; Ober, Kathleen; Hagerich, Kelley; Gerlan, Cindy; Ganji, Gelareh; Lee, Euyhyun; Proudfoot, James A.; Grunvald, Eduardo; Gupta, Samir; Ho, Samuel B.; Zarrinpar, Amir
- Abstract
<bold>Objective: </bold>This study aimed to evaluate a possible association between the use of obesogenic medications and inadequate weight loss in a behavioral weight-management program.<bold>Methods: </bold>This is a case-control, single-center study of 666 adult patients within a Veterans Health Administration health system who participated in the MOVE! behavioral weight-loss program. The cohort was divided into responders (n = 150), patients who achieved ≥ 5% total weight loss by the end of the MOVE! program, and nonresponders (n = 516), those who achieved < 5% total weight loss. We reviewed each patient's medical records for exposure to obesogenic medication during the time of treatment.<bold>Results: </bold>Approximately 62% (n = 411) of patients entering MOVE! had a prescription for obesogenic medications. Obesogenic medication use was associated with worse weight-loss outcomes, and participants were 37% less likely to achieve a clinically meaningful (≥ 5% total weight loss) outcome at the end of the MOVE! program (odds ratio, 0.633; 95% CI: 0.427-0.937; adjusted P = 0.022). Patients who received three or more medications (n = 72) had the greatest difficulty achieving 5% weight loss compared with the control group (odds ratio, 0.265; 95% CI: 0.108-0.646; adjusted P = 0.003).<bold>Conclusions: </bold>The use of provider-prescribed obesogenic medications was associated with worse weight-loss outcomes in a behavioral weight-loss program. Closer scrutiny of patient medications is necessary to help improve outcomes of weight-loss treatments.
- Subjects
UNITED States. Veterans Health Administration; WEIGHT loss; VETERANS' health; HEALTH services administration; ODDS ratio; DRUGS; COMPARATIVE studies; HEALTH promotion; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; RETROSPECTIVE studies; CASE-control method
- Publication
Obesity (19307381), 2019, Vol 27, Issue 5, p716
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22444