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- Title
Aerobic exercise training does not alter vascular structure and function in chronic obstructive pulmonary disease.
- Authors
Gelinas, Jinelle C.; Lewis, Nia C.; Harper, Megan I.; Melzer, Bernie; Agar, Gloria; Rolf, J. Douglass; Eves, Neil D.
- Abstract
New Findings What is the central question of this study? Chronic obstructive pulmonary disease (COPD) is associated with endothelial dysfunction, arterial stiffness and systemic inflammation, which are linked to increased cardiovascular disease risk. We asked whether periodized aerobic exercise training could improve vascular structure and function in patients with COPD., What is the main finding and its importance? Eight weeks of periodized aerobic training did not improve endothelial function, arterial stiffness or systemic inflammation in COPD, despite improvements in aerobic capacity, blood pressure and dyspnoea. Short-term training programmes may not be long enough to improve vascular-related cardiovascular risk in COPD., Chronic obstructive pulmonary disease (COPD) has been associated with endothelial dysfunction and arterial stiffening, which are predictive of future cardiovascular events. Although aerobic exercise improves vascular function in healthy individuals and those with chronic disease, it is unknown whether aerobic exercise can positively modify the vasculature in COPD. We examined the effects of 8 weeks of periodized aerobic training on vascular structure and function and inflammation in 24 patients with COPD (age, 69 ± 7 years; forced expiratory volume in 1 second as a percentage of predicted (FEV1%pred), 68 ± 19%) and 20 matched control subjects (age, 64 ± 5 years; FEV1%pred, 113 ± 16%) for comparison. Endothelial function was measured using brachial artery flow-mediated dilatation, whereas central and peripheral pulse wave velocity, carotid artery intima-media thickness, carotid compliance, distensibility and β-stiffness index were measured using applanation tonometry and ultrasound. Peak aerobic power (
- Subjects
OBSTRUCTIVE lung diseases; CARDIOVASCULAR diseases; PHYSIOLOGICAL aspects of aerobic exercises; ARTERIAL diseases; MEACHAM syndrome
- Publication
Experimental Physiology, 2017, Vol 102, Issue 11, p1548
- ISSN
0958-0670
- Publication type
Article
- DOI
10.1113/EP086379