Found: 8

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  • Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.

    Published in:
    Cancer & Metabolism, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40170-019-0202-2
    By:
    • Nelson, Barbara S.;
    • Lin, Lin;
    • Kremer, Daniel M.;
    • Sousa, Cristovão M.;
    • Cotta-Ramusino, Cecilia;
    • Myers, Amy;
    • Ramos, Johanna;
    • Gao, Tina;
    • Kovalenko, Ilya;
    • Wilder-Romans, Kari;
    • Dresser, Joseph;
    • Davis, Mary;
    • Lee, Ho-Joon;
    • Nwosu, Zeribe C.;
    • Campit, Scott;
    • Mashadova, Oksana;
    • Nicolay, Brandon N.;
    • Tolstyka, Zachary P.;
    • Halbrook, Christopher J.;
    • Chandrasekaran, Sriram
    Publication type:
    Article

  • Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

    Published in:
    Journal of Pathology, 2018, v. 245, n. 3, p. 324, doi. 10.1002/path.5085
    By:
    • Svoboda, Laurie K.;
    • Teh, Selina Shiqing K.;
    • Sud, Sudha;
    • Kerk, Samuel;
    • Zebolsky, Aaron;
    • Treichel, Sydney;
    • Thomas, Dafydd;
    • Halbrook, Christopher J.;
    • Lee, Ho‐Joon;
    • Kremer, Daniel;
    • Zhang, Li;
    • Klossowski, Szymon;
    • Bankhead, Armand R.;
    • Magnuson, Brian;
    • Ljungman, Mats;
    • Cierpicki, Tomasz;
    • Grembecka, Jolanta;
    • Lyssiotis, Costas A.;
    • Lawlor, Elizabeth R.
    Publication type:
    Article

  • GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24859-2
    By:
    • Kremer, Daniel M.;
    • Nelson, Barbara S.;
    • Lin, Lin;
    • Yarosz, Emily L.;
    • Halbrook, Christopher J.;
    • Kerk, Samuel A.;
    • Sajjakulnukit, Peter;
    • Myers, Amy;
    • Thurston, Galloway;
    • Hou, Sean W.;
    • Carpenter, Eileen S.;
    • Andren, Anthony C.;
    • Nwosu, Zeribe C.;
    • Cusmano, Nicholas;
    • Wisner, Stephanie;
    • Mbah, Nneka E.;
    • Shan, Mengrou;
    • Das, Nupur K.;
    • Magnuson, Brian;
    • Little, Andrew C.
    Publication type:
    Article

  • Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway.

    Published in:
    eLife, 2022, p. 1, doi. 10.7554/eLife.73796
    By:
    • Boyer, Seth;
    • Ho-Joon Lee;
    • Steele, Nina;
    • Li Zhang;
    • Sajjakulnukit, Peter;
    • Andren, Anthony;
    • Ward, Matthew H.;
    • Singh, Rima;
    • Basrur, Venkatesha;
    • Yaqing Zhang;
    • Nesvizhskii, Alexey I.;
    • di Magliano, Marina Pasca;
    • Halbrook, Christopher J.;
    • Lyssiotis, Costas A.
    Publication type:
    Article

  • Hyaluronic acid fuels pancreatic cancer cell growth.

    Published in:
    eLife, 2022, p. 1, doi. 10.7554/eLife.62645
    By:
    • Kim, Peter K.;
    • Halbrook, Christopher J.;
    • Kerk, Samuel A.;
    • Radyk, Megan;
    • Wisner, Stephanie;
    • Kremer, Daniel M.;
    • Sajjakulnukit, Peter;
    • Andren, Anthony;
    • Hou, Sean W.;
    • Trivedi, Ayush;
    • Thurston, Galloway;
    • Anand, Abhinav;
    • Liang Yan;
    • Salamanca-Cardona, Lucia;
    • Welling, Samuel D.;
    • Li Zhang;
    • Pratt, Matthew R.;
    • Keshari, Kayvan R.;
    • Haoqiang Ying;
    • Lyssiotis, Costas A.
    Publication type:
    Article

  • Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.

    Published in:
    PLoS ONE, 2024, v. 19, n. 6, p. 1, doi. 10.1371/journal.pone.0303577
    By:
    • Alektiar, Jonathan M.;
    • Shan, Mengrou;
    • Radyk, Megan D.;
    • Zhang, Li;
    • Halbrook, Christopher J.;
    • Lin, Lin;
    • Espinoza, Carlos;
    • Mier, Ivan F.;
    • Lavoie, Brooke L.;
    • Salvatore, Lucie;
    • Pasca di Magliano, Marina;
    • Cantley, Lewis C.;
    • Mueller, Jacob L.;
    • Lyssiotis, Costas A.
    Publication type:
    Article

  • Arginase 1 is a key driver of immune suppression in pancreatic cancer.

    Published in:
    eLife, 2023, p. 1, doi. 10.7554/eLife.80721
    By:
    • Menjivar, Rosa E.;
    • Nwosu, Zeribe C.;
    • Wenting Du;
    • Donahue, Katelyn L.;
    • Hong, Hanna S.;
    • Espinoza, Carlos;
    • Brown, Kristee;
    • Velez-Delgado, Ashley;
    • Wei Yan;
    • Lima, Fatima;
    • Bischoff, Allison;
    • Kadiyala, Padma;
    • Salas-Escabillas, Daniel;
    • Crawford, Howard C.;
    • Bednar, Filip;
    • Carpenter, Eileen;
    • Yaqing Zhang;
    • Halbrook, Christopher J.;
    • Lyssiotis, Costas A.;
    • di Magliano, Marina Pasca
    Publication type:
    Article

  • Purine metabolism regulates DNA repair and therapy resistance in glioblastoma.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17512-x
    By:
    • Zhou, Weihua;
    • Yao, Yangyang;
    • Scott, Andrew J.;
    • Wilder-Romans, Kari;
    • Dresser, Joseph J.;
    • Werner, Christian K.;
    • Sun, Hanshi;
    • Pratt, Drew;
    • Sajjakulnukit, Peter;
    • Zhao, Shuang G.;
    • Davis, Mary;
    • Nelson, Barbara S.;
    • Halbrook, Christopher J.;
    • Zhang, Li;
    • Gatto, Francesco;
    • Umemura, Yoshie;
    • Walker, Angela K.;
    • Kachman, Maureen;
    • Sarkaria, Jann N.;
    • Xiong, Jianping
    Publication type:
    Article