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- Title
Ferritin in cancer therapy: A pleiotropic tumoraffin nanocage-based transport.
- Authors
Guodong Deng; Yang Li; Ning Liang; Pingping Hu; Yan Zhang; Lili Qiao; Yingying Zhang; Jian Xie; Hui Luo; Fei Wang; Fangjie Chen; Fengjun Liu; Deguo Xu; Jiandong Zhang
- Abstract
Background: Ferritin, a ubiquitously distributed iron storage protein, can specifically target tumor cells through transferrin receptor 1. Due to its rearrangeable nanocage structure, ferritin can be loaded with anticancer drugs. Combined with amino acid modifications on the outer- and/or inner-spaces of the nanocage, ferritins can be further coupled with antigens, antibodies, and nucleotide sequences. Since ferritin is naturally presented in the human body, when used in vivo, ferritin exhibits good biocompatibility, and no immunogenic response occurs. These makes ferritin an ideal nanocarrier which shows broad application prospects in cancer therapy. Methods: In this study, to find articles, a search was made in PubMed with the keywords ferritin, drug delivery, drug delivery, and cancer treatment. Results: According to the investigation, some studies suggest that ferritin can be loaded with drugs and targeted for delivery to tumor tissue. Therefore, ferritin nanocarriers loaded with drugs can be used in chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT) and immunotherapy. Importantly, the specific targeting of ferritin nanocarriers to tumor cells increases the effectiveness of related therapies and reduces side effects. Conclusions: We conclude in this paper that the superior properties of ferritin nanocarriers as an emerging drug delivery system make them a promising cancer treatment strategy. In the future, it is worth conducting clinical trials to further investigate the safety and efficacy of ferritin nanocarriers in patients.
- Subjects
FERRITIN; TRANSFERRIN receptors; CANCER treatment; DRUG delivery systems; IRON proteins
- Publication
Cancer Medicine, 2023, Vol 12, Issue 10, p11570
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.5778