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- Title
Transient macular edema after intracameral injection of a moderately elevated dose of cefuroxime during phacoemulsification surgery.
- Authors
Wong, David C.; Waxman, Michael D.; Herrinton, Lisa J.; Shorstein, Neal H.
- Abstract
<bold>Importance: </bold>Intracameral injection of cefuroxime sodium (1 mg/0.1 mL) has been reported to reduce the risk of endophthalmitis following cataract surgery. In the United States it must be compounded, which is subject to dilution error. We describe a series of 13 eyes that received intracameral injection of cefuroxime sodium, 9 mg/0.1 mL, intraoperatively.<bold>Observations: </bold>On postoperative day 1, 6 of 13 eyes (46%; 95% CI, 19%-75%) had visual acuity of 20/70 or worse and macular edema. Spectral-domain optical coherence tomography of 2 eyes revealed central subfield thicknesses of 909 and 873 µm. On postoperative day 4, the mean (SD) central subfield thickness was 309 (78) µm in the 6 eyes with diagnosed macular edema, 279 (23) µm in the fellow eyes, and 271 (38) µm in the 7 exposed eyes without macular edema. The mean (SD) time to resolution of macular edema was 5.2 (1.3) days; the final central subfield thickness ranged from 193 to 293 µm. All eyes, except 2 with preexisting ocular comorbidity, had a best-corrected final visual acuity at 1 month of 20/30 or better. Significant corneal edema was not observed.<bold>Conclusions and Relevance: </bold>Intracameral injection of cefuroxime sodium at a dose of 9 mg/0.1 mL was associated with transient macular edema and diminished visual acuity in 6 of 13 exposed eyes (46%), resolving largely within 1 week.
- Subjects
ANTERIOR chamber (Eye); ANTIBIOTICS; CEFUROXIME; DOSAGE forms of drugs; INJECTIONS; INTRAOCULAR lenses; LONGITUDINAL method; PHACOEMULSIFICATION; RESEARCH funding; RETINAL degeneration; VISUAL acuity; OPTICAL coherence tomography; DIAGNOSIS
- Publication
JAMA Ophthalmology, 2015, Vol 133, Issue 10, p1194
- ISSN
2168-6165
- Publication type
journal article
- DOI
10.1001/jamaophthalmol.2015.2421