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- Title
Dapagliflozin increases the lean-to total mass ratio in type 2 diabetes mellitus.
- Authors
Wolf, Vaneza Lira W.; Breder, Ikaro; de Carvalho, Luiz Sérgio F.; Soares, Alexandre A. S.; Cintra, Riobaldo M.; Barreto, Joaquim; Munhoz, Daniel B.; Kimura-Medorima, Sheila T.; Nadruz, Wilson; Guerra-Júnior, Gil; Quinaglia, Thiago; Muscelli, Elza; Sposito, Andrei C.
- Abstract
We compared the effect of dapagliflozin versus glibenclamide on the ratio of lean-to total mass in patients with type 2 diabetes mellitus, carotid subclinical atherosclerosis, HbA1c 7.0–9.0% and 40–70 years-old. Ninety-eight patients (61% male; mean age 57 ± 7 years) were randomized into dapagliflozin 10 mg/day or glibenclamide 5 mg/day on top of metformin. Body composition was measured by Dual Energy X-Ray at randomization and after 12 weeks of treatment. Glycemic control was equivalent in both groups. Dapagliflozin decreased total body mass (−2741 g [95% CI: −3360 to 1945]; p < 0.001) and lean mass (−347 g [95% CI: −761 to −106]; p < 0.001), while glibenclamide increased total body mass (1060 g [95% CI: 140 to 1836]; p < 0.001) and lean mass (929 g [95% CI: 575 to 1283]; p < 0.001) for the differences between arms. The lean-to-total mass ratio increased by 1.2% in the dapagliflozin group and 0,018% in the glibenclamide group (p < 0.001). Dapagliflozin reduced the risk of a negative balance in the lean-to total mass ratio [OR: 0.16 (95% CI: 0.05 to 0.45); p < 0.001] even after adjustment for baseline lean-to total mass ratio, waist circumference, HOMAIR, HbA1c, mean of the two hands handgrip strength and gait speed [OR: 0.13 (95% CI: 0.03–0.57); p < 0.007]. In conclusion, under equivalent glycemic control, dapagliflozin reduced total body mass but increased the ratio of lean-to-total mass when compared with glibenclamide.
- Subjects
DAPAGLIFLOZIN; TYPE 2 diabetes; GLIBENCLAMIDE; ATHEROSCLEROSIS; METFORMIN
- Publication
Nutrition & Diabetes, 2021, Vol 11, Issue 1, p1
- ISSN
2044-4052
- Publication type
Article
- DOI
10.1038/s41387-021-00160-5