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- Title
AP-1B: polarized sorting at the endosome.
- Authors
Traub, Linton M.; Apodaca, Gerard
- Abstract
Reveals how the epithelial-specific adaptor protein complex AP-1B operates and challenges the idea that export to the basolateral plasma membrane occurs solely from the trans-Golgi network (TGN). Requirement of selective protein trafficking to establish and preserve distinct apical and basolateral surfaces for polarized epithelia; Maintenance of cell polarization by dedicated protein sorting pathways; Control of basolateral targeting by tyrosine- or dileucine-based sorting signals within the cytosolic portion of integral membrane proteins.
- Subjects
EPITHELIUM; CELL membranes; TYROSINE; MEMBRANE proteins
- Publication
Nature Cell Biology, 2003, Vol 5, Issue 12, p1045
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1203-1045