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- Title
Differentiation and regulation of the corticotropic pituitary cell.
- Authors
Petersenn, S.; Schulte, H. M.
- Abstract
A number of primary diseases of the pituitary with adrenocorticotropin dysregulation have been recognized. A few genetic defects have been identified as causes of secondary adrenocortical insufficiency. Much less is known about the ontogeny of corticotrophic tumours leading to a hypercorticolaemic state. To improve the diagnosis and treatment of these disorders, a better understanding of the mechanisms of corticotrophic pituitary cell differentiation and regulation is of clear interest. Studies using molecular tools have enhanced our knowledge over recent years, and a few reports of considerable relevance are summarized in this review.
- Subjects
CORTICOTROPIN releasing hormone; PITUITARY hormone releasing factors; ADRENOCORTICOTROPIC hormone; HYPOTHALAMIC-pituitary-adrenal axis; BIOSYNTHESIS
- Publication
European Journal of Clinical Investigation, 2000, Vol 30, p10
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1046/j.1365-2362.2000.0300s3010.x