We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats.
- Authors
Alkan, E.; Ugan, R. A.; Basar, M. M.; Halici, Z.; Karakus, E.; Balbay, M. D.; Un, H.
- Abstract
To evaluate the protective role of bosentan ( BOS), an endothelin-1 ( ET-1) receptor antagonist, and to show the changes in rats with experimentally induced diabetic erectile dysfunction ( ED), a total of 24 albino Wistar rats were allocated into four groups. Group 1 was the healthy group and Group 2 had diabetes mellitus ( DM) induced by intraperitoneal injection of 60 mg kg−1 streptozotocin ( STZ). Following the establishment of DM, Group 3 and Group 4 were treated with oral BOS doses of 50 mg kg−1 and 100 mg kg−1, respectively, for 60 days. At the end of the treatment, we evaluated yawning and erection response to apomorphine treatment and then the animals were sacrificed. ET-1, eNOS, iNOS, tumour necrosis factor ( TNF)-α, ET- RA and ET- RB mRNA expressions were analysed in cavernosal tissue. It was observed that yawning and erection response decreased in the diabetic group; however, both of these improved with BOS treatment. While ET-1, TNF-α and iNOS gene expressions increased, eNOS, ET- RA and ET- RB gene expressions decreased in the DM group compared to the healthy group. DM has a negative impact on cavernosal tissue blood flow through activating vasoconstrictor mediators in cavernosal tissue. BOS regulates significantly eNOS, iNOS and TNF-α expressions in a dose-dependent manner.
- Subjects
ENDOTHELIN receptors; NITRIC-oxide synthases; IMPOTENCE; STREPTOZOTOCIN; BLOOD flow
- Publication
Andrologia, 2017, Vol 49, Issue 2, pn/a
- ISSN
0303-4569
- Publication type
Article
- DOI
10.1111/and.12607