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- Title
Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives.
- Authors
Hussain, Abid; Kashif, Muhammad; Naseer, Muhammad; Rana, Usman; Hameed, Shahid
- Abstract
A series of new 3-arylsulfonylimidazolidine-2,4-diones ( 2a- 2p) were synthesized by reacting imidazolidine-2,4-diones ( 1a- 1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones ( 1a- 1e) were in turn synthesized from the corresponding ketones through Bucherer-Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR, H and C NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds ( 2a- 2p) was evaluated using alloxanized diabetic rat model. Compound 2a showed an excellent activity with a reduction in the blood glucose level of −286 ± 7 mg/dL after 5 h of drug administration as compared to −270 ± 8 mg/dL for glipizide. The hypoglycemic activity of compound 2b (−268 ± 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound 2e.
- Subjects
HYPOGLYCEMIC agents; IMIDAZOLIDINES; HETEROCYCLIC compounds; NITROMETHYLENE compounds; AMINE synthesis
- Publication
Research on Chemical Intermediates, 2015, Vol 41, Issue 10, p7313
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-014-1814-3