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- Title
Remaining symptoms in half the children treated for milk allergy.
- Authors
Petrus, Nicole; Schoemaker, Anne-Fleur; Hoek, Meike; Jansen, Laura; Jansen-van der Weide, Marijke; Aalderen, Wim; Sprikkelman, Aline
- Abstract
The aim of this study was to investigate the cumulative incidence and predictive variables of treatment failure with a whey-based extensively hydrolyzed formula (w-eHF) in children with cow's milk allergy (CMA). All children were diagnosed with CMA, using double-blind placebo-controlled food challenge (DBPCFC) with amino acid-based formula as placebo, and receive w-eHF treatment after diagnosis. Forty-nine children with CMA were included. w-eHF treatment failure was defined as incomplete resolution of original CMA symptoms upon w-eHF treatment and disappearance of these symptoms upon replacement of w-eHF with amino acid-based formula. A multiple logistic regression model was used to investigate which variables could predict treatment failure. Twenty-five (51 %; 95 % confidence interval (CI) 38-64 %) of the children with CMA failed on w-eHF. Only 'gastrointestinal discomfort' was found to contribute independently to the probability of failing w-eHF, odds ratio (95 % CI) 8.994 (1.007-79.457). Conclusions: In half of the children with proven CMA, there is incomplete resolution of symptoms upon w-eHF treatment. This study needs to be repeated including DBPCFC with w-eHF to provide more definitive diagnosis, especially since gastrointestinal discomfort seems to be the sole predictive variable for treatment failure. In the meantime, a change in formula should be considered in children with incomplete symptom resolution upon w-eHF treatment.
- Subjects
MILK allergy; SYMPTOMS; JUVENILE diseases; LOGISTIC regression analysis; DIAGNOSIS; ALLERGY treatment
- Publication
European Journal of Pediatrics, 2015, Vol 174, Issue 6, p759
- ISSN
0340-6199
- Publication type
Article
- DOI
10.1007/s00431-014-2456-6