We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.
- Authors
MacAlpine, Jessie; Daniel-Ivad, Martin; Liu, Zhongle; Yano, Junko; Revie, Nicole M.; Todd, Robert T.; Stogios, Peter J.; Sanchez, Hiram; O'Meara, Teresa R.; Tompkins, Thomas A.; Savchenko, Alexei; Selmecki, Anna; Veri, Amanda O.; Andes, David R.; Fidel Jr., Paul L.; Robbins, Nicole; Nodwell, Justin; Whitesell, Luke; Cowen, Leah E.
- Abstract
This addendum to an article published in Nature Communications discusses a correction to the original findings. The original article reported that a molecule produced by Lactobacillus species inhibits the ability of the fungal pathogen Candida albicans to transition into a more virulent form. However, it was later discovered that the presence of the molecule in the Lactobacillus-conditioned medium was not due to bacterial biosynthesis, but rather a result of chemical reactions during the sterilization process. The correction clarifies that while the molecule does have the ability to block Candida albicans morphogenesis, it is not synthesized by the bacteria. The other findings related to the molecule's mode of action and therapeutic potential remain valid.
- Subjects
CHEMICAL reactions; STERILIZATION (Disinfection); CANDIDA albicans; SMALL molecules; MECHANICAL heat treatment
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Correction Notice
- DOI
10.1038/s41467-024-50740-z