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- Title
Cholesteryl-ester transfer protein enhances the ability of high-density lipoprotein to inhibit low-density lipoprotein oxidation.
- Authors
Hine, David; Mackness, Bharti; Mackness, Mike
- Abstract
Therapeutic strategies to increase high-density lipoprotein (HDL) to treat or prevent vascular disease include the use of cholesteryl-ester transfer protein (CETP) inhibitors. Here, we show, to the best of our knowledge for the first time, that addition of CETP to HDL enhances the ability of HDL to inhibit low-density lipoprotein oxidation by ∼ 30% for total HDL and HDL2 (both P < 0.05) and 75% for HDL3 ( P < 0.01). Therefore, CETP inhibition may be detrimental to the antiatherosclerotic properties of HDL, and these findings may partly explain the failure of the CETP inhibitor, torcetrapib, treatment to retard vascular disease despite large increases in HDL, in addition to its 'off target' toxicity, a property which appears not to be shared by other members of this class of CETP inhibitor currently under clinical trial. Further, detailed studies are urgently required. © 2011 IUBMB IUBMB Life, 63(9): 772-774, 2011
- Subjects
ESTERS; HIGH density lipoproteins; LOW density lipoprotein absorption &; adsorption; OXIDATION; CARDIOVASCULAR disease prevention
- Publication
IUBMB Life, 2011, Vol 63, Issue 9, p772
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.508