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- Title
Inhibition of Tumor Angiogenesis by Targeting Endothelial Surface ATP Synthase with Sangivamycin.
- Authors
Komi, Yusuke; Ohno, Osamu; Suzuki, Yasuhiro; Shimamura, Mariko; Shimokado, Kentaro; Umezawa, Kazuo; Kojima, Soichi
- Abstract
Background: Sangivamycin, an antibiotic with anti-tumor and anti-herpes virus activities by inhibiting both DNA/RNA synthesis and protein kinase C activity, was reported to suppress selectively DNA synthesis and growth of human umbilical vein endothelial cells and their tube formation in vitro. Here, to address the potential clinical use of sangivamycin in future, we investigated its anti-angiogenic effect in in vivo chicken chorioallantoic membrane (CAM) and mouse dorsal air sac (DAS) assays, and investigated underlying mechanism.
- Publication
Japanese Journal of Clinical Oncology, 2007, Vol 37, Issue 11, p867
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hym115