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- Title
EVALUATING INTRANEURIAL FIBROSIS AND MICROVASCULAR ARCHITECTURE LOSS: AN ESSENTIAL FINDING IN INEFECTIVE HUMAN NERVE GRAFTS.
- Authors
Suman, Soni; Anees, Shahnawaz; Sharma, Sushant Kumar; Kumar, Bhartendu; Choudhary, V. P.
- Abstract
Background: Clinical nerve repair frequently makes use of processed nerve allografts. Allograft failure, however, has a high recorded incidence rate and has been associated with persistent pain and loss of function. Aim: Using immune-histochemistry and histological analysis, the current study aimed to assess the failed allograft healing in a sensory human nerve one year following the first procedure. Methods: Four patients who had superficial radial nerve damage were repaired using processed nerve allografts. At the follow-up visit, the clinical data showed no reinnervations of sensory nerves and considerable neuropathic pain. The failed transplant was removed, and then histologic and immune-histochemical tests were performed. The midpoint of the specimens was examined for collagen content, lymphatic and blood vasculature, and the neurofilament network. Results: Increased fibrosis, fatty degeneration, and abnormal nerve fibre development were all seen upon histologic investigation. The microvascular network of the allografts also showed a discernible pattern, with an increase in microvessels and no change in the lymphatic vasculature. In summary, the current study concludes that loss of microvascular and physiologic architecture is associated with human allograft failure, within the limitations of the investigation. To further understand the mechanism behind the failure of human nerve allografts, more clinical research is needed to assess the interplay between angiogenesis, lymphangiogenesis, and axonal regeneration.
- Subjects
NERVE grafting; RADIAL nerve; NERVOUS system regeneration; FATTY degeneration; CHRONIC pain
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 1, p912
- ISSN
0975-3583
- Publication type
Article