We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin D Status in Bipolar Disorder.
- Authors
Späth, Zita; Tmava-Berisha, Adelina; Fellendorf, Frederike T.; Stross, Tatjana; Maget, Alexander; Platzer, Martina; Bengesser, Susanne A.; Häussl, Alfred; Zwigl, Ina; Birner, Armin; Queissner, Robert; Stix, Katharina; Wels, Linda; Lenger, Melanie; Dalkner, Nina; Zelzer, Sieglinde; Herrmann, Markus; Reininghaus, Eva Z.
- Abstract
Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, and the vitamin D metabolite ratio (VMR) in BD and correlated the results with clinical affective symptomatology and functionality. The inactive precursor 25(OH)D, and its principal catabolite 24,25(OH)2D, were measured simultaneously with a validated liquid chromatography–tandem mass spectrometry method in 170 BD outpatients and 138 healthy controls. VMR was calculated as follows: VMR = 100×(24,25(OH)2D/25(OH)D). The psychometric assessment comprised: Beck Depression Inventory-II, Hamilton Depression Rating Scale, Young Mania Rating Scale, Global Assessment of Functioning, and number of suicide attempts. We did not find a significant difference between patients and controls in the concentrations of 25(OH)D and 24,25(OH)2D. Additionally, the VMR was comparable in both groups. The calculations for the clinical parameters showed a negative correlation between the Young Mania Rating Scale and 24,25(OH)2D (r = −0.154, p = 0.040), as well as the Young Mania Rating Scale and the VMR (r = −0.238, p = 0.015). Based on the small effect size and the predominantly euthymic sample, further exploration in individuals with manic symptoms would be needed to confirm this association. In addition, long-term clinical markers and an assessment in different phases of the disease may provide additional insights.
- Subjects
VITAMIN D metabolism; BIOMARKERS; FUNCTIONAL status; CROSS-sectional method; LIQUID chromatography; EFFECT sizes (Statistics); MENTAL health; PSYCHOMETRICS; SUICIDAL behavior; SEVERITY of illness index; MASS spectrometry; DESCRIPTIVE statistics; MENTAL depression; AFFECTIVE disorders; VITAMIN D deficiency; DATA analysis software; BIPOLAR disorder; METABOLITES; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 22, p4752
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15224752