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- Title
Sleep Deprivation and Central Appetite Regulation.
- Authors
Liu, Shuailing; Wang, Xiya; Zheng, Qian; Gao, Lanyue; Sun, Qi
- Abstract
Research shows that reduced sleep duration is related to an increased risk of obesity. The relationship between sleep deprivation and obesity, type 2 diabetes, and other chronic diseases may be related to the imbalance of appetite regulation. To comprehensively illustrate the specific relationship between sleep deprivation and appetite regulation, this review introduces the pathophysiology of sleep deprivation, the research cutting edge of animal models, and the central regulatory mechanism of appetite under sleep deprivation. This paper summarizes the changes in appetite-related hormones orexin, ghrelin, leptin, and insulin secretion caused by long-term sleep deprivation based on the epidemiology data and animal studies that have established sleep deprivation models. Moreover, this review analyzes the potential mechanism of associations between appetite regulation and sleep deprivation, providing more clues on further studies and new strategies to access obesity and metabolic disease.
- Subjects
OBESITY risk factors; CHRONIC disease risk factors; RISK of childhood obesity; BIOLOGICAL models; CHRONOBIOLOGY disorders; RISK assessment; TYPE 2 diabetes; SLEEP deprivation; EATING disorders; DISEASE risk factors
- Publication
Nutrients, 2022, Vol 14, Issue 24, p5196
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14245196