We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system.
- Authors
Tiwari, Sandip; Murthy, T.; Raveendra Pai, M.; Mehta, Pavak; Chowdary, Pasula
- Abstract
The effect of concentration of hydrophilic (hydroxypropyl methylcellulose [HPMC]) and hydrophobic polymers (hydrogenated castor oil [HCO], ethylcellulose) on the release rate of tramadol was studied. Hydrophilic matrix tablets were prepared by wet granulation technique, while hydrophobic (wax) matrix tablets were prepared by melt granulation technique and in vitro dissolution studies were performed using United States Pharmacopeia (USP) apparatus type II. Hydrophobic matrix tablets resulted in sustained in vitro drug release (>20 hours) as compared with hydrophilic matrix tablets (<14 hours). The presence of ethylcellulose in either of the matrix systems prolonged the release rate of the drug. Tablets prepared by combination of hydrophilic and hydrophobic polymers failed to prolong the drug release beyond 12 hours. The effect of ethylcellulose coating (Surelease) and the presence of lactose and HPMC in the coating composition on the drug release was also investigated. Hydrophobic matrix tablets prepared using HCO were found to be best suited for modulating the delivery of the highly water-soluble drug, tramadol hydrochloride.
- Publication
AAPS PharmSciTech, 2003, Vol 4, Issue 3, p18
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/pt040331