We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Population Genomic Screening for Three Common Hereditary Conditions.
- Authors
Battistuzzi, Linda; Oliani, Cristina; Sciallero, Stefania; Tibiletti, Maria Grazia; Turchetti, Daniela; Varesco, Liliana
- Abstract
A recent article in the Annals of Internal Medicine discusses the potential benefits and drawbacks of population genomic screening for hereditary breast and ovarian cancer syndrome (HBOC), Lynch syndrome (LS), and familial hypercholesterolemia (FH). The authors argue that screening for these conditions using a restricted panel of causative genes could be cost-effective for adults aged 40 and younger, as long as testing costs are low and preventive interventions are accessible. However, they also caution that population-level screening could lead to increased complexity in interpreting results and potential harms such as screening-related distress, genetic discrimination, false-positive results, and health disparities. The authors suggest that informed consent and ethical considerations should be carefully addressed before implementing population genomic screening.
- Subjects
MEDICAL screening; HEREDITARY nonpolyposis colorectal cancer; FAMILIAL hypercholesterolemia; HEALTH equity; OVARIAN cancer; METASTATIC breast cancer
- Publication
Annals of Internal Medicine, 2023, Vol 176, Issue 11, p1
- ISSN
0003-4819
- Publication type
Article
- DOI
10.7326/L23-0321