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- Title
CANCEROGENEZA, UN POSIBIL PROCES DE EVOLUŢIE SAU ADAPTARE CELULARĂ.
- Authors
Ardelean, A.; Pribac, G. C.; Moş, Liana; Montreuil, J.
- Abstract
Mutations of genes that are essential for the cell cycle cause cancer only in specific cell lines (e.g. repair genes in the colon; BRCA1-2 in breast and ovary; neurofibromatosis and xeroderma pigmentosum). The mutation rate of genes other than p53 is the same in colon cancer and in normal cells, indicating that a 'mutator phenotype', increasing the rate of mutations in many genes, is not an essential feature of sporadic cancers; conversely, some genes, typical of leukemia, are 100 times more frequent at birth than in overt leukemia in children, indicating that further selective events are needed to cause malignancy. Carcinogenesis has been traditionally interpreted as the sequence of initiation (mutation) and promotion (clone expansion), with an interesting similarity with the neo-Darwinian theory of evolution, based on a first stage of genetic change (including recombination) and a second stage of selection. As in neo-Darwinian theory selection is chiefly represented by the elimination of the less fit, the selection of mutated cells would mainly consist in resistance to apoptosis.
- Subjects
GENETIC mutation; CELL cycle; CELL lines; COLON cancer; CARCINOGENESIS; SKIN abnormalities; LEUKEMIA; PHENOTYPES; CANCER education; GENETICS
- Publication
Analele Societatii Nationale de Biologie Celulara, 2008, Vol 13, p32
- ISSN
1583-6258
- Publication type
Article