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- Title
I<sub>2</sub>–DMSO‐Mediated Multicomponent [2+1+1+1] Annulation Reaction via Ethyl Nitroacetate C—NO<sub>2</sub> Bond Cleavage as a C1 Synthon: A Route to Multisubstituted β‐Pyrrolidinones Derivatives with a Quaternary Center.
- Authors
Yu, Zhi‐Cheng; Shen, Xi; Zhou, You; Chen, Xiang‐Long; Wang, Li‐Sheng; Wu, Yan‐Dong; Wu, An‐Xin
- Abstract
Comprehensive Summary: A [2 + 1 + 1 + 1] cyclization reaction has been developed for the synthesis of multisubstituted β‐pyrrolidinones from commercially available aryl methyl ketones, primary amines, and ethyl nitroacetate. In this I2–DMSO‐meditated process, the C—NO2 bond of ethyl nitroacetate is cleaved, affording a C1 synthon, and the formation of two C—C and two C—N bonds and a quaternary carbon center are constructed in one pot. This method has good substrate compatibility and permits the late‐stage modification of pharmaceutical compounds.
- Publication
Chinese Journal of Chemistry, 2024, Vol 42, Issue 17, p2029
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202400297