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- Title
Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization.
- Authors
Zhang, Yi; Yang, Peng; Cui, Ran; Zhang, Manna; Li, Hong; Qian, Chunhua; Sheng, Chunjun; Qu, Shen; Bu, Le
- Abstract
Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue. In this review, we focused on the role of eosinophils in regulating metabolic homeostasis and obesity.
- Subjects
EOSINOPHILS; OBESITY; ANTI-inflammatory agents; ADIPOSE tissue physiology; MACROPHAGE activation; CYTOKINES; HOMEOSTASIS
- Publication
International Journal of Endocrinology, 2015, p1
- ISSN
1687-8337
- Publication type
Article
- DOI
10.1155/2015/565760