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- Title
Biochemical investigation of foetal and neonatal thyroid function using the ACS-180SE analyser: clinical application.
- Authors
Guibourdenche, Jean; Noël, Michèle; Chevenne, Didier; Vuillard, Edith; Voluménie, Jean Luc; Polak, Michel; Boissinot, Christine; Porquet, Dominique; Luton, Dominique
- Abstract
Despite sonographic detection of foetal goitre, uncertainty persists in the initial diagnosis of thyrotoxicosis and hypothyroidism. The aim of this study was to establish foetal and neonatal iodothyronine and thyrotrophin reference values for the ACS-180SE analyser. From 22 to 36 weeks of gestation, median foetal serum free thyroxine (FT4) levels increased from 6.0 pmol/L to 14.3pmol/L, while free triiodothyronine (FT3) levels increased from 0.7 pmol/L to 1.9 pmol/L and mean thyrotrophin (TSH) levels remained stable (10.2±3.8 mU/L; n = 33). At birth, concentrations were independent of gender and gestational age. Among the 10 cases of sonographically detected foetal goitre, serum TSH and FT4 were measured in five, showing hypothyroidism (3⁄5) or hyperthyroidism (2⁄5). Cord blood TSH levels reflected the efficacy of prenatal therapy. Measurement of foetal FT4 and TSH can be used to confirm foetal thyroid dysfunction, whereas treatment efficacy can be assessed sonographically and confirmed by measurement of TSH assay at birth.
- Subjects
HYPERTHYROIDISM; IODINE deficiency diseases; THYROID diseases; THYROTROPIN; THYROID hormones; FETAL diseases
- Publication
Annals of Clinical Biochemistry, 2001, Vol 38, Issue 5, p520
- ISSN
0004-5632
- Publication type
Article
- DOI
10.1258/0004563011901334