We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke.
- Authors
Yi-Chen Hsieh; Fang-I Hsieh; Yih-Ru Chen; Chaur-Jong Hu; Jiann-Shing Jeng; Sung-Chun Tang; Nai-Fang Chi; Huey-Juan Lin; Li-Ming Lien; Giia-Sheun Peng; Hung-Yi Chiou
- Abstract
Background: Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes and estradiol levels on the risk of ischemic stroke. Methods: This case-control study was conducted with 624 ischemic stroke patients and 624 age- and gender-matched controls. The PRS estimated the polygenic contribution of inflammatory genes from ischemic stroke susceptibility loci. Estradiol levels were measured using a radioimmunoassay. High and low estradiol levels were defined according to the log-transformed median estradiol levels in female and male controls. Results: Subjects in the fourth quartile of the PRS had a significant 1.57-fold risk of ischemic stroke (95% confidence interval [CI], 1.12 ~ 2.19), after adjusting for covariates compared to individuals in the lowest quartile. Compared to individuals with high estradiol levels and a low PRS as the reference group, those exposed to low estradiol levels and a high PRS had an increased risk of ischemic stroke (odds ratio, 3.35; 95% CI, 1.79 ~ 6.28). Similar results were also observed in males when the analysis was stratified by gender. Conclusions: Our data suggest that the PRS can be useful in evaluating a high risk of ischemic stroke among patients, especially those exposed to low estradiol levels.
- Subjects
STROKE; ESTRADIOL; GENETIC polymorphisms; NEUROPROTECTIVE agents; RADIOIMMUNOASSAY; GENETICS; THERAPEUTICS
- Publication
Journal of Biomedical Science, 2017, Vol 24, p1
- ISSN
1021-7770
- Publication type
Article
- DOI
10.1186/s12929-017-0332-1