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- Title
Comparison of Omeprazole, Levofloxacin, Amoxicillin With Omeprazole, Bismuth Sub-Citrate, Furazolidone, Amoxicillin Treatment Regimens for the Eradication of Helicobacter pylori as a Second-line Therapy.
- Authors
Vafaeimanesh, Jamshid; Seyedmajidi, Mohammad reza
- Abstract
Introduction: Although the prevalence of Helicobacter pylori infection decreased following the hygiene promotion and application of proper anti-H.pylori treatments, unfortunately gradual increase is reported in treatment failure; hence, application of a proper treatment regimen as a second-line therapy is of great importance. Methods: In the current randomized, clinical trial, a total of 120 patients with peptic ulcers who failed to respond to treatment were enrolled. In the OLA group, a regimen of omeprazole 40 mg/day, levofloxacin 1 g/day, and amoxicillin 2 g/day was prescribed; however, a regimen of omeprazole 40 mg/day, bismuth sub-citrate 480 mg/ day, furazolidone 400 mg/day, and amoxicillin 2 g/day was administered to the OFAB group. Both groups were treated for 2 weeks, and 6 weeks after the treatment, the urea breath test (UBT) was performed in the subjects. Collected data were analyzed with SPSS version 18. Results: According to the results of the current study, 96.7% of the subjects in the OLA and 95% in the OFAB groups completed the treatment course and the eradication rates were 86.7% and 78.3% in the OLA and OFAB groups, respectively (P-value = 0.23). Treatment side effects were observed in 51.7% and 11.7% of the subjects in the OLA and OFAB groups, respectively (P < 0.01). Conclusion: Both regimens were applicable as the secondline therapy due to insignificant difference between the results of the 2 groups; however, OLA regiment was superior to OFAB, due to lower side effects.
- Subjects
IRAN; AMOXICILLIN; BISMUTH; CITRATES; CONFERENCES &; conventions; HELICOBACTER pylori; NITROFURANS; OMEPRAZOLE; QUINOLONE antibacterial agents; DISEASE eradication
- Publication
Iranian Journal of Gastroenterology & Hepatology (GOVARESH), 2017, Vol 22, Issue 3, p22
- ISSN
1560-7186
- Publication type
Article