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- Title
Mitochondrial Mutations Affect the Cardiovascular System during Aging and Oxidative Stress.
- Authors
Poznyak, Anastasia V.; Sukhorukov, Vasily N.; Popov, Mikhail A.; Chegodaev, Yegor S.; Postnov, Anton Y.; Orekhov, Alexander N.
- Abstract
Mitochondria are one of the most crucial components of the cell. Aging has a critical impact on mitochondria. Various studies have shown that the relationship between aging and mitochondria is multifaceted. In this review, we focused on mitochondrial DNA mutations and their impact on the cardiovascular system during aging and oxidative stress. While mitochondria contain their own DNA, part of their proteome is encoded by nuclear DNA, which further complicates the inheritance of mitochondrial diseases, making almost all methods of transmission of various pathologies possible. We provide a discussion on mitochondrial DNA mutagenesis and the most common problems associated with mitochondrial DNA mutations.
- Subjects
OXIDATIVE stress; MITOCHONDRIAL DNA; NUCLEAR DNA; CELL anatomy; MITOCHONDRIA; CARDIOVASCULAR system; AGING
- Publication
Gene Expression (1052-2166), 2023, Vol 22, Issue 3, p232
- ISSN
1052-2166
- Publication type
Article
- DOI
10.14218/GE.2023.00039