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- Title
Effect of Ligand Structure on MnO Nanoparticles for Enhanced T<sub>1</sub> Magnetic Resonance Imaging of Inflammatory Macrophages.
- Authors
Park, Joseph; Bang, Doyeon; Kim, Eunjung; Yang, Jaemoon; Lim, Eun-Kyung; Choi, Jihye; Kang, Byunghoon; Suh, Jin-Suck; Park, Hyo Seon; Huh, Yong-Min; Haam, Seungjoo
- Abstract
Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages.
- Subjects
CARBOXYMETHYL compounds; DEXTRAN; MAGNESIUM oxide; METALS spectra; NANOPARTICLES; MAGNETIC resonance imaging
- Publication
European Journal of Inorganic Chemistry, 2012, Vol 2012, Issue 36, p5960
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201201026