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- Title
Inhibitory effect of dibutyryl chitin ester on nitric oxide and prostaglandin E production in LPS-stimulated RAW 264.7 cells.
- Authors
Jeon, In; Mok, Ji; Park, Kwang-Hyun; Hwang, Hee; Song, Mi; Lee, Duckhee; Lee, Min; Lee, Woo-Yiel; Chai, Kyu; Jang, Seon
- Abstract
Inflammation is a highly complex process that protects against foreign challenge or tissue injury. The ester derivative dibutyryl chitin (DBC) reportedly accelerates wound healing and exerts an anti-inflammatory effect. However, little is known regarding the inhibitory effect of DBC in anti-inflammation. In this study, we investigated the effect of DBC on the inducible nitric oxide synthetase (iNOS) and cyclooxygenage-2 (COX-2) pathways and pro-inflammatory cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results demonstrate that DBC (MW 3,772) significantly inhibits overproduction of NO and PGE as well as pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, in LPS-stimulated RAW 264.7 macrophages. Inhibition of NO and PGE overproduction in LPSstimulated RAW 264.7 macrophages by DBC was mediated through the down-regulation of iNOS and COX-2 expression. These results demonstrate that DBC efficiently inhibits inflammation and has potential as an effective anti-inflammatory and wound healing agent.
- Publication
Archives of Pharmacal Research, 2012, Vol 35, Issue 7, p1287
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-012-0720-8