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- Title
Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones.
- Authors
Jung, Sang-Hun; Lee, Hui-Soon; Kim, Nam-Soo; Kim, Hwan-Mook; Lee, Moonsun; Choi, Dong-Rack; Lee, Jung-Ah; Chung, Yong-Ho; Moon, Eun-Yi; Hwang, Hyun-Sook; Seong, Seung-Kyoo; Lee, Dug-Keun
- Abstract
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4, 5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
- Publication
Archives of Pharmacal Research, 2004, Vol 27, Issue 5, p478
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02980119