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- Title
Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population.
- Authors
Bahl, Ankur; Kumar, Pankaj; Dar, Lalit; Mohanti, Bidhu K.; Sharma, Atul; Thakar, Alok; Karthikeyan, Venkat; Sikka, Kapil; Singh, Chiromamit; Poo, Kamala; Lodha, Jaini
- Abstract
Background Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive. Methods One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior. Results HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor. Conclusion Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status. © 2013 Wiley Periodicals, Inc. Head Neck 36: 505-510, 2014
- Subjects
PAPILLOMAVIRUSES; ALCOHOL drinking; POLYMERASE chain reaction; DNA polymerases; SQUAMOUS cell carcinoma
- Publication
Head & Neck, 2014, Vol 36, Issue 4, p505
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23317