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- Title
Evaluation of the role of imidazolidinone motif of antineoplas-tic 4-phenyl-1-arylsulfonylimidazolidinones using 4-phenyl-2-aryl-sulfonyloxazolines.
- Authors
Jung, Sang-Hun; Park, Kyung-Lae; Lee, Hui-Soon; Whang, Jee-Sun
- Abstract
To evaluate the role of imidazolidinone moiety of potential anticancer 4-phenyl-1 -arylsulfonylimidazolidinones 1 for their cytotoxicity, conformationally similar 4-phenyl-2-arylsulfonylaminooxazolines 2 were synthesized and compared their cytotoxicities with those of the corresponding 1. Compounds 2 showed much reduced activity compared to N-arylsulfonylimidazolidinones 1. This result might indicate that the imidazolidinone ring of 1 have the other roles for the activity as an essential structural motif in addition to conformational contribution.
- Publication
Archives of Pharmacal Research, 2001, Vol 24, Issue 6, p499
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02975152