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- Title
Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent.
- Authors
Cheon, Seung; Park, Joon; Chung, Byung-Ho; Choi, Bo-Gil; Cho, Won-Jea; Choi, Sang-Un; Lee, Chong-Ock
- Abstract
A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidaz[2,1- a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound ( 15) exhibited the best antitumor activity which is 3–5 times better than 5-[4′-(piperidinomethyl) phenyl]-2,3-dihydroimidazo[2,1- a]isoquinoline ( 1).
- Publication
Archives of Pharmacal Research, 1998, Vol 21, Issue 2, p193
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02974027