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- Title
Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer.
- Authors
Burbure, Nina; Handorf, Elizabeth; Ridge, John A.; Bauman, Jessica; Liu, Jeffrey C.; Giri, Anshu; Galloway, Thomas J.
- Abstract
Background: Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB). Methods: There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016. The association between treatment modality and survival was analyzed using Kaplan–Meier survival curves and multivariable Cox regression. Results: Five‐year overall survival ranged from 45% for stage I to 21% for stage IVB. Treatment modality did not influence survival in stage I/II. For stage III/IV, chemoradiation and surgery + adjuvant therapy were equivalent. Surgery yielded improved survival for T4 disease. Human papillomavirus (HPV)‐positive tumors were present in 21% and were associated with improved hazard ratio of death (0.60, p = <0.0001). Conclusions: Survival is superior for T4 hypopharynx cancer managed with surgery, while treatment modality does not impact outcomes for other T‐stages. HPV‐positive tumors are associated with improved survival regardless of treatment.
- Subjects
HYPOPHARYNGEAL cancer; SURVIVAL analysis (Biometry); OVERALL survival; CHEMORADIOTHERAPY; LARYNGEAL cancer; PAPILLOMAVIRUSES; ONCOLOGIC surgery; CANCER diagnosis
- Publication
Head & Neck, 2021, Vol 43, Issue 10, p3042
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26793