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- Title
High prevalence of papillary thyroid cancer in Korean women with insulin resistance.
- Authors
Bae, Min Jung; Kim, Sang Soo; Kim, Won Jin; Yi, Yang Seon; Jeon, Yun Kyung; Kim, Bo Hyun; Lee, Byung Joo; Lee, Jin Choon; Kim, In Joo; Wang, Soo Geun; Kim, Yong Ki
- Abstract
Background The purpose of this study was to determine if hyperinsulinemia and/or insulin resistance are/is associated with the prevalence of papillary thyroid cancer (PTC) in Korean women. Methods This study included 735 female patients with PTC and 537 female non-PTC control subjects. Multiple logistic regression analysis was performed to evaluate the associations between hyperinsulinemia/insulin resistance and the occurrence of PTC. Results The prevalence of PTC was significantly correlated with increased insulin, glucose levels, and a high homeostasis model of assessment-insulin resistance (HOMA-IR). The multivariate adjusted odds ratios for the prevalence of PTC in the highest quartile groups for insulin, glucose, and HOMA-IR were 2.88, 9.32, and 4.07 (all p < .001), respectively, compared with the lowest quartile groups. Pathological analyses revealed that increased serum glucose, insulin levels, and a higher HOMA-IR were associated with the multifocality of PTC. Conclusion Hyperinsulinemia and/or insulin resistance may be associated with the development of PTC, but not disease severity in Korean women.
- Subjects
KOREA; DISEASE prevalence; THYROID cancer; WOMEN; INSULIN resistance; DISEASES in women; LOGISTIC regression analysis; GLUCOSE
- Publication
Head & Neck, 2016, Vol 38, Issue 1, p66
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23848