We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Circulating stem cells in extremely preterm neonates.
- Authors
Bizzarro, Matthew J; Bhandari, Vineet; Krause, Diane S; Smith, Brian R; Gross, Ian
- Abstract
Aim: To measure circulating CD34+ cell levels in premature neonates and to correlate the initial CD34+ counts with measures of pulmonary function and neonatal morbidity. Methods: CD34+ cell counts were measured in the peripheral blood of preterm neonates (gestational ages 24–32 weeks) ventilated for respiratory disease at <48 h of life, and at the start of the 2nd, 3rd and 4th weeks of life. Data pertaining to neonatal demographics and short-term outcomes were collected. Pulmonary function tests were performed to coincide with CD34+ sampling. Results: Thirty preterm neonates with median gestational age of 24 weeks and birth weight of 641 g were analysed. A mean of 99.4 CD34+ cells per microliter was observed in the 1st week of life with a decline to 54.4 cells per microliter by the 4th week. An inverse correlation between initial CD34+ count and gestational age (p = 0.01) was observed. No significant correlations were observed with measures of pulmonary function or neonatal morbidities. Conclusions: Extremely premature neonates have remarkably high levels of CD34+ cells in their peripheral blood at birth. Umbilical cord blood from this population may potentially provide an abundant source of hematopoietic stem and progenitor cells for therapeutic purposes.
- Subjects
NEONATAL diseases; PULMONARY function tests for newborn infants; PREMATURE infants; HEMATOPOIETIC stem cells; NEWBORN infants; STEM cell treatment; UMBILICAL cord; PEDIATRIC respiratory diseases; MEDICAL research
- Publication
Acta Paediatrica, 2007, Vol 96, Issue 4, p521
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/j.1651-2227.2007.00194.x