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- Title
Pain unresponsive to high dose opiate drugs.
- Authors
Dickson, Robert J; Russell, Psb
- Abstract
Rarely the pain from malignant disease, primary or metastatic, cannot be adequately relieved by conventional analgesics, even with very high dosage opiate drugs. It is now recognized that in many instances this pain, of deafferentation type, is due to actual nerve infiltration or destruction by tumour. Five such cases are reported, in each of whom, a different manipulation of drug therapy was necessary before adequate pain control was achieved. It is concluded that, until a better understanding of the mechanism of deafferentation pain is reached, treatment of such cases will remain unsatisfactory.
- Publication
Palliative Medicine, 1989, Vol 3, Issue 1, p61
- ISSN
0269-2163
- Publication type
Article
- DOI
10.1177/026921638900300110