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- Title
Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
- Authors
Rabinak, Christine; Sripada, Chandra; Angstadt, Mike; Wit, Harriet; Phan, K.
- Abstract
Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
- Subjects
CANNABINOIDS; EMOTIONS; PLACEBOS; MAGNETIC resonance imaging; TETRAHYDROCANNABINOL; AMYGDALOID body
- Publication
Journal of Neural Transmission, 2012, Vol 119, Issue 6, p701
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-011-0747-x