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- Title
Napsin A Expression in Primary Mucin-Producing Adenocarcinomas of the Lung.
- Authors
Wu, Jeffrey; Chu, Peiguo G.; Zhong Jiang; Lau, Sean K.
- Abstract
Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with signet ring cell features, as well as in 25 extrapulmonary mucinous adenocarcinomas of different anatomic sites. Immunohistochemical expression of thyroid transcription factor 1 (TTF-1) was also compared. Thirty-three percent of mucinous lung tumors exhibited positive immunoreactivity for napsin A, whereas 42% expressed TTF-1. All 25 extrapulmonary mucinous adenocarcinomas lacked expression of napsin A and TTF-1. Mucin-producing neoplasms of the lung infrequently express napsin A, suggesting that immunohistochemical assessment of napsin A may have limited diagnostic usefulness for distinguishing primary and metastatic mucinous adenocarcinomas involving the lung.
- Subjects
IMMUNOHISTOCHEMISTRY; TUMORS; ADENOCARCINOMA; TRANSCRIPTION factors; METASTASIS
- Publication
American Journal of Clinical Pathology, 2013, Vol 139, Issue 2, p160
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCP62WJUAMSZCOM