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- Title
Novel 3‐substituted N‐methylcarbazole–imidazolium salt derivatives: Synthesis and cytotoxic activity.
- Authors
Li, Yan‐hua; Zhou, Bei; Shi, Yi‐min; Xun, Yu‐peng; Yang, Yun‐han; Yang, Li‐juan
- Abstract
A series of novel 3‐substituted N‐methylcarbazole–imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of tumor cell lines (Hep G‐2, Hela and PC12). The results suggest that the presence of substituted 2‐methyl‐imidazole or imidazole ring and substitution of the imidazolyl‐3‐position with a naphthylacyl or 4‐bromophenacyl group were important for improving cytotoxic activity. Compounds 17, 18, 27, and 28 with 4‐bromophenacyl and naphthylacyl groups displayed good activities with IC50 values of 0.09–7.20 μ m against three tumor cell lines investigated and more active than DDP. Compound 35 exhibited cytotoxic activity selectively against Hela cell.
- Subjects
CARBAZOLE derivatives; IMIDAZOLES; CELL-mediated cytotoxicity; STRUCTURE-activity relationship in pharmacology; ANTINEOPLASTIC agents
- Publication
Chemical Biology & Drug Design, 2018, Vol 92, Issue 1, p1206
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.13178