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- Title
The impact of taxane-based preoperative chemotherapy in gastroesophageal signet ring cell adenocarcinomas.
- Authors
Kim, Stefano; Fiteni, Frederic; Paget-Bailly, Sophie; Ghiringhelli, François; Lakkis, Zaher; Jary, Marine; Fein, Francine; Bonnetain, Franck; Mariette, Christophe; Borg, Christophe
- Abstract
The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy on this subtype is still an unresolved issue. Nineteen patients with localized signet ring cell adenocarcinomas received taxane-based regimens, and 17 patients underwent surgery. Complete resection was achieved in 80%, and median overall survival was 40.8 months (95% confidence interval (CI), 20.2--not reached). Even though one patient achieved a complete pathological response, seven patients had an upstaging of their tumors at surgery. The potential benefits of taxane-based chemotherapy seem to be limited to a reduced number of patients.
- Subjects
CANCER chemotherapy; ONCOLOGIC surgery; HISTOLOGY; TAXANES; TUMORS; HEART failure
- Publication
Journal of Hematology & Oncology, 2015, Vol 8, Issue 1, p1
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/s13045-015-0148-y