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- Title
VENTILATION PERFUSION RELATIONSHIPS BETWEEN TRANSPLANTED AND EMPHYSEMATOUS LUNGS.
- Authors
Koerner, Spencer K.; Veith, Frank J.
- Abstract
The extremely short survival of patients receiving single lung allografts for emphysema has been blamed on severe ventilation perfusion (V/Q) imbalance. Papain induced emphysema was produced in dogs followed by left lung allotransplantation to study the relationship of ventilation to perfusion in the transplant and the remaining emphysematous lung. During periods when the transplanted lung was free of infiltrate, there was minimal ventilation perfusion imbalance and the resultant venous admixture was less than 15% of the cardiac output. Only when extensive infiltrates were present in the transplant did severe anoxia, indicative of marked V/Q imbalance, occur. The results do not support the concept that the physiologic setting, per se, contraindicates single lung transplantation for emphysema.
- Subjects
LUNG transplantation; TRANSPLANTATION of organs, tissues, etc.; HOMOGRAFTS; PERFUSION; PULMONARY emphysema
- Publication
Vascular Surgery, 1974, Vol 8, Issue 5, p283
- ISSN
0042-2835
- Publication type
Article
- DOI
10.1177/153857447400800504