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- Title
Fas and FasL Polymorphisms Are Not Associated with Acute Myeloid Leukemia Risk in Koreans.
- Authors
Hyun Jeong Kim; Xue Mei Jin; Hee-Nam Kim; Il-Kwon Lee; Kyeong-Soo Park; Moo Rim Park; Deog Yeon Jo; Jong Ho Won; Jae-Yong Kwak; Hyeoung-Joon Kim; Jin-Su Choi; Sang Woo Juhng; Choi, Chan
- Abstract
Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation. They have been associated with esophageal, lung, uterine cervical, and urinary bladder cancers in human. We performed a case-control study to investigate the association between Fas and FasL polymorphisms and acute myeloid leukemia (AML) risk. Fas−1377G>A (rs2234767), −670T>C (rs1800682), and FasL−844T>C (rs763110) polymorphisms in 592 AML patients and 858 healthy controls were genotyped and tested for associations between polymorphisms and AML risk. There were no significant differences in genotypic and haplotypic distributions and gene-gene interaction between patients and controls in the overall analysis ( p > 0.05). These results suggested that polymorphisms of Fas and FasL genes were not associated with AML risk in the Korean population.
- Subjects
KOREA; GENETIC polymorphism research; ACUTE myeloid leukemia; LIGANDS (Biochemistry); KOREANS; APOPTOSIS; GENETICS; HEALTH; DISEASE risk factors
- Publication
DNA & Cell Biology, 2010, Vol 29, Issue 10, p619
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/dna.2010.1032