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- Title
Increased muscle echointensity correlates with clinical disability and muscle strength in chronic inflammatory demyelinating polyneuropathy.
- Authors
Fisse, Anna Lena; Fiegert, Sean; Stoykova, Zornitsa; Brünger, Jil; Athanasopoulos, Diamantis; Grüter, Thomas; Motte, Jeremias; Gold, Ralf; Pitarokoili, Kalliopi
- Abstract
Background and purpose: We evaluated muscle echointensity as a marker for secondary axonal damage in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) using ultrasonography. Findings were correlated with clinical disability and muscular strength. Methods: Eighty patients with CIDP (40 with typical and 40 with atypical CIDP) were examined clinically, including assessment of Medical Research Council (MRC) sum score and Inflammatory Neuropathy Cause and Treatment Overall Disability Sum Score (INCAT‐ODSS). Echointensity in eight proximal and distal muscles of the arms and legs was evaluated by muscle ultrasonography using the Heckmatt scale. Results: Alterations of echointensity occurred most frequently in the distal leg muscles, with a median (range) Heckmatt score of 1.5 (1–4). There were no differences between typical and atypical CIDP patients with regard to Heckmatt score. Alterations of echointensity correlated to disability and muscle strength. The arm score of the INCAT‐ODSS correlated to Heckmatt score for the distal arm muscles (r = 0.23, p = 0.046) and the leg score of the INCAT‐ODSS correlated to Heckmatt scores for the proximal (r = 0.34, p = 0.002) and distal leg muscles (r = 0.33, p = 0.004). MRC sum score, as well as individual MRC scores for arm and leg muscles, correlated to Heckmatt scores of the corresponding muscle groups (r = −0.25, p = 0.02 for MRC sum score). Conclusion: Increased muscle echointensity, reflecting fibrosis and fatty infiltration due to secondary axonal damage, correlated to muscular strength and disability in a large cohort of CIDP patients. Alterations of echointensity occur in both typical and atypical CIDP patients and are pronounced in the distal leg muscles.
- Subjects
MEDICAL Research Council (Great Britain); MUSCLE strength; CHRONIC inflammatory demyelinating polyradiculoneuropathy; DISABILITIES; LEG muscles; MEDICAL research; ARM muscles; ULTRASONIC imaging
- Publication
European Journal of Neurology, 2021, Vol 28, Issue 5, p1698
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/ene.14716