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- Title
An expedient synthesis of novel 2-substituted thiazolo[4,5-f] isoquinolines/quinolines and benzo[1,2-d:4,3-d']bisthiazoles and their potential as inhibitors of COX-1 and COX-2.
- Authors
Chakrabarty, Manas; Mukherji, Ajanta; Karmakar, Sulakshana; Mukherjee, Ratna; Nagai, Kenichiro; Geronikaki, Athina; Eleni, Pitta
- Abstract
An efficient, general synthesis of 2-substituted thiazolo[4,5-f]isoquinolines, thiazolo[4,5-f]-quinolines and benzo[1,2-d:4,3-d']bisthiazoles has been accomplished from 5-nitroisoquinoline/quinoline and 6-nitrobenzothiazole, respectively, and all the products have been thoroughly identified spectroscopically (IR, 1H and 13C NMR, LR/ HR EI/ FAB/ ESI-MS). The synthesis of thiazolo[4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities.
- Subjects
BIOSYNTHESIS; ISOQUINOLINE; QUINOLINE; SPECTRUM analysis; NOMIFENSINE; QUINOIDINE; AROMATIC compounds
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2010, p265
- ISSN
1551-7004
- Publication type
Article