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- Title
Microwave-assisted Sonogashira coupling of novel 2-[6-(arylethynyl)pyridin-3-yl]-1H-benzimidazole derivatives.
- Authors
Raut, Changdev Namdev; Mane, Ramchandra Bhimrao; Bagul, Sandeep Mukunda; Janrao, Ravindra Ashok; Mahulikar, Pramod Pandurang
- Abstract
A rapid and efficient method for the synthesis of novel 2-[6-(arylethynyl)pyridin-3-yl]-1H-benzimidazole derivatives under microwave-assisted Sonogashira coupling conditions has been developed. The method avoids the use of protecting groups for benzimidazole NH during Sonogashira coupling. The microwave-assisted method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates.
- Subjects
ORGANIC synthesis research; RESEARCH methodology; SUBSTRATES (Materials science); BENZIMIDAZOLES; PARAOXONASE; PYRIDINIUM compounds; AMINOPYRIDINES; ASTEMIZOLE; PYRIDINE
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2009, p105
- ISSN
1551-7004
- Publication type
Article